Pace® Life Sciences provides a full suite of contract CMC development, CTM manufacturing, regulatory compliance, consulting, and facility support services to the pharmaceutical, biopharmaceutical, and gene therapy industries from our network of CDMO sites, GMP analytical testing laboratories, and manufacturing support service centers. Our experienced, highly trained industry experts, and our investment in state-of-the-art development and manufacturing facilities emphasizes our commitment to efficiently advancing client programs through the clinic to commercialization. We share a common goal to bring real value to people, healthcare professionals and health businesses around the world. Driven by our commitment to improve our health, we deliver services that offer hope – and a better, safer and healthier life for everyone.

Summary

We seek a highly motivated scientist with industry experience in analytical method development to support method and formulation development of oligonucleotides such as siRNA, ASO, and PMOs. Our clients include biotechnology and pharmaceutical companies from new startups to those with global operations. Competitive applicants will be able to demonstrate an in-depth knowledge of techniques to manipulate and characterize oligonucleotides, an ability to collaborate in a dynamic and fast changing environment, creative problem solving, and excellent oral as well as written communication skills. This is a full-time scientist position in Woburn, MA with title commensurate to experience.

Responsibilities include:

• Lead project teams that solve technical problems and meet quality standards.
• Routinely communicate with clients to present results and describe planned experiments clearly and concisely both verbally and in written documents.
• Independently design and execute experiments, analyze data, and present results.
• Supervise, manage, and train a team of 2 – 4 junior scientists.
• Strive to meet agreed-upon timelines and regularly communicate progress to stakeholders.
• Maintain a strong awareness of scientific literature relevant to nucleic acid therapeutics.
• Continuously improve research and development skills to advance technical capabilities of Pace.
• Write persuasive proposals for prospective clients with clearly defined scope of work, duration/schedule, and deliverables.

Required background and experience includes:

• Ph.D. in chemistry, biochemistry, molecular and cellular biology, or closely related discipline. Title will be commensurate with education and years of experience. M.S. candidates with 12+ years of industry experience and Ph.D. candidates with 6+ years of industry and relevant academic experience will be considered at the Senior Scientist level.
• Hands-on experience in chromatography (SEC, IEX, & IPRP HPLC/UPLC), spectroscopy (UV, CD), and mass spectrometry (LC-MS, LC-MS/MS) of therapeutic oligonucleotides.
• Established track record of significant contributions as an individual technical expert as well as the ability to thrive in a multi-disciplinary team environment.
• Development and use of analytical methods for identity, assay, purity/impurity, and characterization of large molecules such as oligonucleotides, gRNA, mRNA, peptides, or proteins. Experience with analytical method validation is also desired.
• Formulation of oligonucleotides for various routes of administration. Experience in the lyophilization of drug products is also desired.
• Outstanding written and oral communication skills as well as polished presentation skills.
• Ability to manage people and projects

PHYSICAL/MENTAL REQUIREMENTS:

The physical demands described herein are representative of those that must be met by an employee to successfully perform the essential functions of the job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Mobility to work in a lab and office setting, use standard office and lab equipment and stamina to sit for extended periods of time; exerting up to 20 pounds of force occasionally and/or up to 10 pounds of force frequently to lift, carry, push, pull or move objects; vision to read printed materials and computer screens; and hearing and speech to communicate in person or over the telephone. Senior Scientists will be required to work longer days from time to time to complete a project or finish job responsibilities.

WORKING ENVIRONMENT:

Work is performed in a lab and office setting. Work is subject to chemicals, fumes, gasses, noxious odors and related items in a lab setting.

OFCCP Statement:

Pace Life Sciences, LLC is an Equal Opportunity Employer and will not discriminate against any applicant for employment on the basis of race, age, religion, sex, veterans, individuals with disabilities, sexual orientation, or gender identity.

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